Physical nanochitin hydrogel was investigated for prolonged release of microemulsion <i>in vitro</i> conditions. A strong composite hydrogel was prepared by an alkali gas phase coagulation bath composting nanochitin with an oil in water (o/w) microemulsion, in which a hydrophobic dye, Nile Red, was embedded to simulate a drug release process. Different release conditions, such as concentration of nanochitin, diameter of microemulsion, temperature and so on, were studied. The results showed that the nanochitin/microemulsion composite hydrogel effectively encapsulated microemulsion with a prolonged release period of 60 h in phosphate-buffered saline (PBS pH 7.4, similar to physiological conditions), which demonstrated the significance of nanochitin hydrogels for drug delivery application.

<i>In vitro</i> release of microemulsion from nanochtin hydrogel

2019 Spring National Meeting

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In vitro release of microemulsion from nanochtin hydrogel