In recent years, dihydropyrimidinones have significantly become more important for pharmaceutical research due to the diversity of biological activities that they exhibit. Dihydropyrimidinones often are synthesized via the Biginelli reaction, which consists of a three component cyclocondensation reaction between a beta-ketoester, urea, and an aldehyde. The classic Biginelli reaction can give in low reaction yields and requires prolonged reaction times. Therefore, this study explores the use of urea as an organocatalyst for the Biginelli reaction due to its low toxicity and availability. Microwave irradiation was also explored to decrease reaction times. Moderate yield improvements were seen using various urea derivatives as a catalyst in order to synthesize dihydropyrimidinones via microwave irradiation.

Urea-catalyzed Biginelli reaction via microwave irradiation

2019 Spring National Meeting

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