Heterocycles are intimate part of drug discovery research. Many frontline commercial drugs, natural, semi-synthetic or synthetic, contain heterocyclic core in their structures. Several heterocyclic scaffolds are well-known in organic and medicinal chemistry. On the other hand, microwave-irradiation are being used for more than three decades to synthesize new and novel heterocycles and it has been identified as one of the most promising green techniques. Recently, we have synthesized 6H-chromeno[4,3-b]quinolin-6-one core under controlled microwave-irradiation. Till now, 6H-chromeno[4,3-b]quinolin-6-one moiety has been rarely explored. No catalyst/support/additive was used to accomplish the synthesis. Excellent overall conversion, easy work-up method, shorter reaction period as well as preservation of atom-economy are few interesting features of this green procedure.

Microwave-assisted sustainable entry to 6H-chromeno[4,3-b]quinolin-6-ones

2019 Spring National Meeting

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