A systematic kinetics study on dirhodium catalyst within the cyclopropanation reaction was conducted to understand the detailed mechanism of the catalytic cycle as well as the effect of the ligands’ structure. By RPKA study, the robustness of catalyst and the concentration dependence of reagents were determined. It was confirmed that the catalytic activity is retained as the reaction progresses. Although dirhodium catalysts with different ligands exhibit different reaction rates, as seen in the figure with 0.0025 mol% catalyst loading, all of them achieve at least 40,000 turnover numbers. The research gains a refined understanding of the factors that govern catalyst activity and stability, especially under high turnover number conditions. The results can lead to the design of more efficient and practical Rh(II) catalysts to enhance the practicality of the donor/acceptor carbene chemistry by operating under ultra-low catalyst loadings.

<i>In situ </i>kinetic studies to develop rhodium-catalyzed cyclopropanation with extremely high catalyst turnover number

2019 Spring National Meeting

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In situ kinetic studies to develop rhodium-catalyzed cyclopropanation with extremely high catalyst turnover number