In this study, a protocol to install remote Csp3-Csp2 bonds has been established. Specifically, this selective C-H arylation strategy provides access to a wide array of δ-aryl sulfonamides bearing various functional groups in moderate to excellent yields. Mechanistic and selectivity investigations provide evidence that the reaction operates via intramolecular hydrogen atom transfer. Additionally, arylation occurs via a reductive elimination of an alkyl-Cu complex, which is evidenced by the moderate enantioselectivity observed when employing chiral ligands.

C-H arylation via Cu-catalyzed radical relay

2019 Spring National Meeting

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