Galectins are a family of β-galactoside binding lectins with an evolutionarily conserved carbohydrate recognition domain (CRD). To date, fifteen members of the galectin family have been identified in mammals. Combined, galectins have been shown to play critically important roles in cell cycle regulation, cell-cell, cell-matrix and protein interactions, intracellular signaling, inflammation and apoptosis through the binding of glycoconjugates. Galectins are also involved in tumorigenesis. Here we present the synthesis of a series of new carbohydrate analogs to better understand the role of galectins in tumor migration. Our ongoing work on the evaluation of these compound will also be discussed.

Development of new carbohydrate analogs for studying the role of galectins in tumor migration

2019 Spring National Meeting

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