Resveratrol is a naturally occurring polyphenol found in grapes, certain berries, and few nuts. Research on the compound has shown biomedical promise as an anti-cancer agent as well as lowering the risk of heart disease. While research into stilbenes in pharmaceutical use has progressed, the synthetic processes are still time-consuming. Excess use of metal and organic waste can also have a detrimental effect on the environment. Herein, we show the successful synthesis of novel resveratrol analogues inside a ball mill. This process results in higher yields in a shorter amount of time compared to other methods. We perform these microscale green reactions without the use of solvent or transition-metal catalysts. These analogues are currently being tested on cancer cells to eventually develop new treatments. At present, several synthesized analogues show great promise in inhibiting metastasis. Results will be presented in further detail.

Green synthesis of novel resveratrol analogues for cancer research

2019 Spring National Meeting

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