Water-tolerant metathesis catalysts are of enormous interest in applications ranging from pharmaceutical manufacturing (given the water content of technical grade solvents), to metathesis of algal oils, and the far horizon of metathesis in biological media. The important ruthenium metathesis catalysts have long been presumed to tolerate water. Recent findings will be discussed which demonstrate that such tolerance is commonly predicated on highly reactive substrates, and high catalyst loadings. The mechanisms underlying catalyst decomposition will be explored, with an eye to identifying design criteria for new, water-tolerant catalysts.<br/>

Water-tolerant olefin metathesis: Challenges and opportunities

2019 Spring National Meeting

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