<br/>The current methods of functionalization of the polyesters involve the coupling of the polyesters with the single ligand. We, herein, describe the design and development of dual-headed nanosystems for improved drug delivery across the biological barriers. The chemical modification of the commercially available polylactide-co-glycolide (PLGA) having one terminal carboxylic end with linkers with two functional heads which permits coupling with two similar or different ligands. These functional polyesters upon emulsification lead to submicron sized particles encapsulating a wide range of drugs with different physicochemical attributes. These dual-headed polymer based nanosystems show better bioavailability of the encapsulated compounds as compared to single-headed systems.

Design and development of dual-headed nanosystems: Drug delivery applications

2019 Spring National Meeting

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