γ-Curcumene is a sesquiterpenoid that is found in a variety of essential oils, including Helichrysum italicum and Pogostemon cablin. The natural product possesses a reactive cyclic diene system that could serve as a biogenic precursor for more complex sesquiterpene families. Our progress towards an enantioselective four-step synthesis of γ-curcumene from (S)-citronellal will be presented. Efforts towards developing a unified route to access each member of the curcumene natural product family will also be discussed.

Total synthesis of γ-curcumene

2019 Spring National Meeting

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