Calcium oxide (CaO) nanoparticles have different applications in biomedical fields. These particles are object of ongoing research for the design of drug delivery systems. Some of their properties are size distribution, biocompatibility and biodegradability. Our work reports the synthesis of calcium oxide microparticles and nanoparticles acquired by co- precipitation method of calcium chloride and sodium hydroxide. The CaO particles were obtained by the thermal decomposition of Ca(OH)<sub>2</sub>. Different synthesis parameters were varied, including addition of PVP to stabilize the particles and prevent agglomeration, calcination time and concentration of reactants. Different size CaO particles were obtained, ranging from 50 nm to 150 nm. Stabilities of these particles were evaluated and characterized by UV – VIS spectroscopy, Diffracted Light Scattering (DLS), FTIR and Scanning Electron Microscopy (SEM). Applications of these particles for loading and release of drugs were evaluated using different addition volumes by spontaneous adsorption. Drug loading was dependent of the selected drug. The experiments were performed with ibuprofen and curcumin. Loading capacity varies from 48% to 55% respectively at 24 hours. More studies to validate the method will be conducted.

Synthesis of calcium oxide microparticles and nanoparticles: A comparative study of spontaneous adsorption for drug loading

2019 Spring National Meeting

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