Pyridoxal, a vitamer of vitamin B6, can undergo facile thermal ortho-pyridinone methide (o-PM) formation and react with alcohol and amine nucleophiles. Progress towards engaging the ortho-pyridinone methide intermediate π-system coupling partners in cycloaddition chemistry is presented.

Efforts towards cycloadditions with pyridoxal via an ortho-pyridinone methide intermediate

2019 Spring National Meeting

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