Here, we present new approaches for the fabrication of dynamic shape-shifting nanostructures. Dual-responsive DNA diblock copolymers and triblock copolymers were synthesized by coupling a thermo-responsive polymer, poly(N-isopropylacrylamide (PNIPAM) and an oligonucleotide. Such DNA block copolymer micelles can undergo sphere-to-cylinder shape transformation in response to the temperature change and DNA binding events, demonstrating the multi-dimensional dual responsive shape changing capability.  Furthermore, we present a new approach to fabricate dynamic and responsive free standing films of nanoparticles, based on the programmable DNA-directed self-assembly and the layer-by-layer (LbL) thin film fabrication technique. We demonstrate that the new approach provides a powerful means to generate dynamic nanostructures that can undergo complex and programmable shape transformation.

Dynamic nanostructures fabricated by the self-assembly of functional polymers and nanoparticles

2019 Spring National Meeting

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