Hydroamination reactions are a favored approach for the creation of chiral amines, which have proven utility to the pharmaceutical industry. These reactions are ideal due to their atom economic and green characteristics. To date, many reported hydroamination reactions are catalyzed by metals, many of which are endangered due to overuse. Metal catalysts can also be difficult to completely remove from reaction products. Herein, we explore the use of ammonium salts as an organocatalytic alternative for the hydroamination of alkenes. Asymmetric induction via the use of chiral ammonium salts has also been explored.

Hydroamination of unactivated alkenes using organocatalysts

2019 Spring National Meeting

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