Virotherapy has emerged as an innovative method of cancer treatment. Oncolytic viruses can selectively kill cancerous cells while leaving healthy cells unaffected. Additionally, it was found that vanadium compounds enhanced or stimulated the oncolytic potency of the virus in killing cancer. We plan to synthesize novel oxovanadium complexes for use in virotherapy. One area that we will be investigating is thallium derived vanadium catechol complexes, which are prepared from solutions of vanadyl sulfate and catechol derivatives in water with the addition of thallium acetate. After isolation and characterization of these complexes, we will examine their stability in various environments. In addition, we will then evaluate their efficacy with oncolytic viruses for cancer treatment. We believe that these vanadium compounds can be improved by increasing the hydrophobicity of the complex to avoid hydrolysis of the vanadium. We anticipate that the oxovanadium complexes will have at least similar activity to that of previously examined vanadate salt.

Synthesis and characterization of vanadium catecholates for enhancement of oncolytic viruses

2019 Spring National Meeting

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