Different methods for syntheses of functional polyesters based on glycerol or different sugars using Candida antarctica lipase B (CAL-B) are discussed. It is outlined that vinyl endgroups of the polyesters might lead to crosslinked polymers after introducing functional groups to the polyesters via Michael addition. A series of grafted polyesters is produced using different saturated and non-saturated fatty acids having different volume fractions of hydrophobic side chains and also hydrophilic poly(ethylene glycol) side chains are grafted. The hydrophilic-lipophilic balance (HLB) of grafted polyesters is tailored by changing the degree of grafting of hydrophilic and hydrophobic side chains. Polymers are characterized by NMR spectroscopy, differential scanning calorimetry, gel permeation chromatography, and X-ray diffraction. Furthermore, the self-assembly of the graft copolymers and their use as steric stabilizers for cubosomes are investigated. The ternary phase diagram of the system glycerol monooleate (GMO) / water / graft copolymer is studied in detail by SAXS and WAXS measurements. The occurrence of different crystallographic cubic phases and their stability for drug delivery systems is discussed in detail. Furthermore, the linear polyester poly(glycerol adipate) (PGA) was covalently grafted with indomethacin. An interfacial deposition method was employed for the preparation of nanospheres with narrow particle size distribution and the nanoparticles are studied by zeta potential measurements, dynamic light scattering, cryo-electron microscopy and nanoparticle tracking analysis. Cell viability tests were carried out and the cytotoxicity tests using different cell lines showed low toxicity and low hemolytic activity for all samples. A slow and controlled release profile without any burst was observed over 15 days. Thus, the nanoparticles have the potential to improve the therapy of inflammation and related diseases.

Using grafted functional polyesters for drug delivery systems

2019 Spring National Meeting

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