Hydrogen peroxide is one of the key signaling moleucles in human body, but elevated level of hydrogen peroxide contridutes to oxidative stress associated with inflammation and cancer. Here we synthesized aryl boronic ester-decorated polycaprolactone (O-PCL) which could undergo hydrogen peroxide-triggered degradation via hydrolysis of oxidized aryl boronic ester, quinone methide rearrangement and intramolecular cyclization. In addition, we formulated O-PCL nanoparticles and proved that these nanoparticles could release their payload in the presence of biologically relevant levels of hydrogen peroxide. This work provides a potent drug delivery system for tissues with higher levels of hydrogen peroxide.

Hydrogen peroxide-triggered payload release from polycaprolactone-based nanoparticles

2019 Spring National Meeting

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