Naturally occurring and synthetically derived hydroxynaphthoquinones (juglone, lawsone, phthiocol, plumbagin, laphachol) have a wide range of pharmacological uses such as anti-bacterial, anti-fungal, anti-viral, anti-parasitic, anti-inflammatory, anti-proliferative, anti-cancer, and anti-tubercular. The naphthoquinone scaffold is present in the core structure of important therapeutics and biologically active natural products already. Taking advantage of Michael addition reactions, substituents were incorporated to the hydroxynapthoquinone scaffold to create multitudes of 1,4-naphthoquinones. The analogues were tested for their antimicrobial and anticancer properties. In this presentation, development of these novel hydroxynaphthoquinones utilizing an interesting chemical approach will be discussed along with their biological activities.

Modification of hydroxynaphthoquinone scaffold in search of antimicrobial and antineoplastic agents

2019 Spring National Meeting

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