Plasmon-coupled circular dichroism (PCCD) has emerged as an intriguing technique for sensitive detection of biomolecules through strong coupling between molecular chirality and plasmon. However, PCCD observed with ensemble spectroscopy in plasmonic colloids are always biased without considering the presence of some aggregation. Plasmonic aggregates themselves could be chiral, which has been demonstrated by many reports including our extensive single particle work. However, none of this (chiral aggregates) has been considered so far because of the origin of PCCD really not distinguishable with ensemble methods. In this talk, I will discuss our recent work on applying single particle measurements for the first time and can distinguish the different contributions between structural chirality of aggregated nanorods and PCCD induced from chiral proteins. I will also discuss how this work sheds light on designing a better single-particle plasmonic platform for detecting biomolecules at single-molecule level.<br/>

Unraveling the origin of plasmon-coupled circular dichroism from gold nanorod-protein complexes at single-particle level

2019 Spring National Meeting

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