This presentation will describe the preparation of triblock copolymers consisting of a central poly(propylene oxide) (PPO) block that is flanked by zwitterionic polymer blocks. The polymers produced resemble Polaxamers (i.e., PEO-PPO-PEO triblock copolymers) wherein the PEO blocks are replaced with poly(methacryloyloxyethyl phosphorylcholine) (polyMPC) blocks). The synthesis of polyMPC-PPO-polyMPC triblock copolymers is particularly versatile, since inverse zwitterions (i.e., choline phosphates) are easily integrated into the zwitterionic polymer blocks, affording functional versions that can be cross-linked to form robust nanostructures, or utilized in bioconjugation chemistry for the attachment of cancer drugs, peptides, proteins, targeting moieties, etc.

Zwitterionic versions of poloxamers: Functional nanostructures and bioconjugates

2019 Spring National Meeting

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