There is significant interest in identifying new combination therapies that synergize to treat disease, and it is becoming increasingly clear that the temporal resolution of their administration greatly impacts efficacy.  To facilitate effective delivery, we developed a multicompartment hydrogel  composed of spherical vesicles interlaced within a self-assembled peptide-based network of physically crosslinked fibrils that allows time-resolved independent co-delivery of small molecules. Herein, we demonstrate that this material architecture effectively delivers the EGFR kinase inhibitor erlotinib (ERL) and doxorubicin (DOX, DNA intercalator) in an ERL followed by DOX sequential manner to synergistically kill glioblastoma, the most aggressive form of brain cancer.

Multicompartment self-assembled gel that facilitates time-resolved delivery of combination therapy and synergized killing of cancer

2019 Spring National Meeting

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