Amides are extremely important functional groups in synthetic chemistry and biological systems. The traditional organic synthesis of amides is accomplished through coupling reactions, which require the use of activated carboxylic acid derivatives and amines using a coupling/activating reagent. These traditional organic methods, although powerful, can have significate drawbacks including the production of halogenated waste, high reaction temperatures, and low yields. The use of organometallic catalysts have provided an alternative route for the synthesis of amides to address some of these conventional drawbacks. Multiple RuII-catalysts with the general formal Ru(dppb)Cl2(ampy-X), (ampy = 2-(aminomethyl)pyridine; X = Cl or OMe)and [(p-cy)RuCl(xbpy)]+ (X = tBu, Br or OMe) were synthesized, characterized and tested for catalytic amine dehydrogenation. These systems will shed light on the effects of catalytic activity as a function of the electron density of a metal center.

Catalytic amine dehydrogenation using RuII complexes: The effect of electron density of the metal center on catalysis.

2019 Spring National Meeting

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