Hybrid hydrogels composed of low molecular weight gelators (LMWG) and natural or synthetic polymers mark the future trend in hydrogel research. Composite hydrogels for advanced applications such as tissue engineering, drug release, wound dressings and implants. LMWG such as sophoro- and glycolipids are particularly interesting for their stimuli responsiveness and the reversibility of the gelation process. However, their mechanical properties suffer from the weak intermolecular forces that build up the hydrogel, which is a disadvantage in regard to (bio)polymer hydrogels. Silk fibroin, a protein that has been used for decades for its exceptional mechanical properties paired with inherent biocompatibility and degradability forms hydrogels with exceptional mechanical properties. The mechanism of gelation lies in the conformational change of the protein from random coil to very ordered β-sheet structure. However, the process is very slow and irreversible. To overcome the named disadvantages we prepared blends of hydrogels and studied their structural properties with small angle neutron scattering (SANS), rheometry and optical methods to resolve the interplay of improved gelling times, mechanical properties and cell proliferation.

Composite silk-glycolipid hydrogels: symbiosis or simple coexistence?

2019 Spring National Meeting

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