Self-assembly of nanoparticles(drugs and proteins) with different functions and amphiphilic block copolymers to form different morphologies, such as vesicles or micelles, is now playing an important role in biological drug loading. The co-assembly behavior of block copolymers (AB) , drugs(P1) and proteins(P2), was investigated by dissipative molecular dynamics (DPD) simulation. We have achived many morphologies by changing the hydrophobic chain length, the interaction parameters between the hydrophobic/ hydrophilic block and the solvent, the size of drugs or protein. By controlling the concentration of block copolymers and the interaction parameters between the hydrophobic block and the solvent, we have found that the aggregated morphology can change from dispersible micelles to aggregated micelles and further into the vesicles. At the moderate solvent concentrations, the size of the vesicles and the cavity are minimal when the drugs and proteins are of medium size. The self-assembled vesicles and micelles have potential application and broad prospects in the fields of biomedicines.

Self-assembly behavior of drugs and proteins based on amphiphilic block copolymers

2019 Spring National Meeting

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