A new water friendly MCAT-53 [Ru2Cl2 (HCOO)3(p-cymene)] Na (sodium η-6-p-cymene dichloro diruthenium triformato complex) has been developed as a catalyst to effect aromatic C–H bond activation and C–C coupling reactions in water. MCAT-53TMallows directed C–H functionalization with high levels of positional selectivity control for the synthesis of API intermediate of Anacetrapib a CETP inhibitor (OPRD, 2018, 22,9, 1119-1130). MCAT-53TMcatalyst is now commercially available in 40 countries. The catalyst has been proven to be useful for the synthesis of substituted phenyl pyridines, phenyl pyrazoles, phenyl oxazolines and Benzo[h]quinolones and others through N-directed C-H functionalization.

New ruthenium Formato catalyst MCAT-53TM for C-H activation useful for the synthesis of medicinally relevant molecules

2019 Spring National Meeting

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