Natural products are a privileged starting point for the development of novel compounds with biological activity, especially antimicrobial agents.  With the growing occurrence of multidrug resistant bacteria, the need for new antimicrobial compounds with novel mechanisms of action is heightened tremendously. The research presented herein focuses on the utilization of marine natural products as leads for novel antimicrobials that are effective against multidrug resistant organisms like Methicillin Resistant <i>Staphylococcus aureus </i>(MRSA). Specifically, the lipoxazolidinone family of 4-oxazolidinone marine natural products will be discussed. Studies thus far have revealed the lipoxazolidinones and their analogs as exciting lead compounds for antibiotic development and as probes to interrogate the microbial world.

Lipoxazolidinone A and analogs as lead compounds for novel antibiotics

2019 Spring National Meeting

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