Oxazole compounds are prevalent in nature, making them an important biological molecule. Both naturally produced and synthetically made oxazole compounds exhibit multiple medically relevant characteristics such as anti-inflammatory and anti-cancer properties. A simple, one pot synthetic pathway for the creation of multi-substituted oxazole compounds would allow further research to be conducted using these oxazole compounds and advance the production of oxazole-based pharmaceuticals. The method developed by our group is a simple, one step process that results in di-substituted and tri-substituted oxazole compounds from an isonitrile and an isocyanate. The method was optimized through solvent and concentration studies to produce multi-substituted oxazoles regioselectively. The benefits of this synthetic route include use of safer solvents, readily available starting materials, and neutral reaction conditions compared to established methods of oxazole synthesis. Future work on this research project will focus on using our refined method to create libraries of di-substituted and tri-substituted oxazole compounds with varying substituent groups.<br/>

Development of a rapid synthesis of highly substituted oxazoles

2019 Spring National Meeting

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