Recent data indicate 1 in 8 women will develop breast cancer in her lifetime. It is estimated that there will be 266,120 new diagnoses of breast cancer in 2018, and 40,920 women will die of breast cancer in 2018. In pursuit of new potential chemotherapy options to treat breast cancer, our lab has been working to identify components in medicinal plants that may be selectively cytotoxic to breast cancer cells. Ethanolic extracts of Cinnamomum verum (Cinnamon) and Salvia officinalis (Sage) were found to be cytotoxic to the 4T1 murine breast cancer cells as compared to a control epithelial cell line (EpH4-Ev). These cytotoxic effects were measured using CellTiter-Gloluminescent cell viability assays at various concentrations and treatment times. Both Cinnamon and Sage were shown to induce caspase 3 activity in 4T1 breast cancer cells but not in the epithelial control cells (measured by western blot analysis). Work is ongoing to purify the cytotoxic components of these plants and the mechanism(s) by which these components induce 4T1 breast cancer cell death. Bulk purification of these constituents is ongoing through flash chromatography and HPLC.

Components of Cinnamon verum (cinnamon) and Salvia officinalis (Sage) in 4T1 breast cancer cells

2019 Spring National Meeting

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