The asthma drug albuterol is often used with corticosteroids, which present several disadvantages (drug addiction; side effects such as weight gain, headaches, sore throat, etc). Non-steroidal anti-inflammatory drugs (NSAIDs) are used as an alternative to corticosteroids, being prescribed before steroids in the treatment of headaches, fever, neuropathy, etc. Like most drugs, NSAIDs and albuterol drugs are in solid state; the active ingredients are paired with inert inorganic counter ions such as chloride and sulfate anions (Cl- and SO4-) or sodium and potassium cations (Na+ and K+). This, along with the presence of an amine site in the structure of albuterol and a carboxylate anion in NSAIDs, positions these drugs as ideal compounds to be converted into an ionic liquid, a strategy known to overcome the drawbacks of the solid drugs. We previously showed that new dual active albuterol-NSAID ionic salts can be synthesized either via a metathesis reaction (between albuterol hydrochloride and sodium salt derivatives of NSAIDs) or via an acid base reaction (between albuterol free base and NSAIDs as free acids). The new dual functioning asthma drugs provide a safer alternative to corticosteroids and could be delivered transdermal. Therefore the solubility of the compounds in simulated body fluids needs to be investigated. This presentation focuses on the solubility of the synthesized compounds in water and phosphate saline buffer (pH = 7.4) a simulated body fluid that mimics blood, at room temperature and at 37 °C.

Solubility of albuterol-NSAIDs ionic salts

2019 Spring National Meeting

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