Catalysts used in cross-coupling reactions are extremely important in the fields of organic synthesis and medicinal chemistry.  Heterogeneous variants of these catalysts are highly desirable to improve economy through catalyst recycling and to decrease purification needs to separate the toxic metals from the final pharmaceutical product. Palladium nanoparticles have been extensively investigated for heterogeneous cross-coupling catalysis, but compared to the scope of homogeneous catalysts, there is much room for improvement and optimization. We are testing different, novel nanocrystals as heterogeneous metal catalysts under different reaction conditions for known cross-coupling reactions, such as the Kumada and Suzuki reactions.  Adjusting the solvent, aryl halide, temperature, and reaction duration allowed conditions to be optimized.  The outcome of each reaction was analyzed via GC-MS.

Investigating novel nanocrystals as catalysts for heterogeneous cross-coupling reactions

2019 Spring National Meeting

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