According to literature, thiosemicarbazone ligands and their metal complexes have shown certain properties that demonstrate anti-cancer activities. The focus of this work was around the synthesis and characterization of four new compounds: 5-fluoroisatin-4-tert-butyl-3-thiosemicarbazone (5FI-tBTSC), 5-fluoroisatin-4-ethyl-3-thiosemicarbazone (5FI-ETSC), 7-fluoroisatin-4-tert-butyl-3-thiosemicarbazone (7FI-tBTSC), and 7-fluoroisatin-3-ethyl-4-thiosemicarbazide (7FI-ETSC). These compounds were all characterized using NMR spectroscopy. Future syntheses will be completed to form Pd complexes with each of the four ligands, and these complexes will be analyzed to determine if any biologic activity exists, particularly inhibition against the topoisomerase-II-a enzyme. If successful, these compounds could lead to new chemotherapeutic agents.<br/>

Synthesis and characterization of four new fluorine-labelled thiosemicarbazones

2019 Spring National Meeting

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