Ionic liquids (ILs) are generally considered as being simple ionic salts, comprised of a cation and an anion in a 1:1 molar ratio and with melting points below 100 oC. Double salt ionic liquids (DSILs, ionic compounds that are liquid at temperatures below 100 oC) are complex ILs that contain more than two types of ions in their structure: one anion and several cations; one cation and several anions; or several anions and several cations. Although a DSIL can be synthesized by melting/mixing simple ILs, it is considered as being one pure compound. Moreover, DSILs have different physical and/or chemical properties than the ones exhibited by their component single salts. Some properties (e.g., solubility) depend on the chemical interactions between the ions; changing the molar ratio between the component ions can lead to new coulombic interactions between them and to new properties. Therefore one can easily take advantage of this behavior and develop new task specific DSILs.<br/>We previously showed that one can successfully synthesize new simple phenothiazine ILs by using various phenothiazine hydrochlorides as cation precursors and metal carboxylates as anion precursors. Our presentation focuses on applying the DSIL strategy to phenothiazine drugs. We’ll discuss the synthesis and spectroscopic characterization of new DSILs formed by varying the molar ratio between the phenothiazine cation promazine and anions such as docusate (a known penetration enhancer) and various carboxylates (i.e., non-steroidal anti-inflammatory drugs, NSAIDs).

Double salt ionic liquids based on phenothiazine cations and various anions

2019 Spring National Meeting

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