Monoacetals derived from pentaerythriol and substituted benzaldehydes are useful intemediates in a variety of synthetic applications. Our previous work expanded the substrate scope of Collard’s selective monoacetal formation within an advanced undergraduate laboratory setting, in which two-dimensional NMR is utilized to elucidate molecular structure. In an effort to expand the synthetic utility of this user-friendly and environmentally benign reaction, we are exploring possible synthetic routes, starting from the monoacetal, (2-(4-bromophenyl)-1,3-dioxane-5,5-diyl)dimethanol.

Expanding the scope and utility of pentaerythritol acetal formation

2019 Spring National Meeting

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