51V NMR spectroscopy is used to document the effect of different vanadate salts on the growth of two mycobacterial strains. The studies presented demonstrate that large orange-colored sodium decavanadate (V10O6−28) anion was found to be a stronger inhibitor of growth of two mycobacterial species than the colorless oxovanadate prepared from sodium metavanadate, thus demonstrating selectivity in its interaction with cells. The vanadium(V) speciation was found to be critical for the observed growth inhibition. 51V NMR spectroscopy and speciation calculations were used to monitor the vanadium(V) speciation in the growth media and conversion among species under growth conditions. The findings demonstrated that V-Citrate (VCit) and vanadate-phosphate (PV) complexes should form as predicted by the speciation analysis and reflect the equilibrium mixture observed by NMR analysis. The findings presented in this work is particularly important in considering the many applications of oxometalates in biological and medical studies and investigating the interactions of oxometalates with other biological systems.

Decavanadate is a more potent growth inhibitor of two mycobacteria strains than other oxovanadates

2019 Spring National Meeting

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