Liposomes are the most widely studied synthetic carriers worldwide for nucleic acid (NA) and drug delivery applications. Cationic liposomes (CLs) are relatively safe vectors used in ongoing clinical trials. The talk will first describe experiments with surface-functionalized PEGylated CL–DNA nanoparticles (NPs), including fluorescence microscopy colocalization with members of the Rab GTPases, which has revealed NP pathways and interactions with cells. The functionalization, achieved through custom synthesis, is intended to address and overcome cell targeting and endosomal escape barriers to delivery faced by NPs designed for in vivo applications. We will further discuss recent results with CL-paclitaxel (PTXL) NPs involving a mechanistic understanding of the relation between structure and physicochemical properties of CL-PTXL NPs and PTXL delivery efficacy leading to cytotoxicity against human cancer cells.

Functionalized lipid carriers for nucleic-acid and drug therapeutics

2019 Spring National Meeting

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