Smart materials have been studied for decades and are continuing to make progress in various fields, including sensors and drug release. Among those responsive materials are self-immolative polymers that allow for end-to-end depolymerization and the ability to release a desired cargo on demand or amplify analyte detection. However, in typical SIP systems, the triggering event leads to a relatively uncontrolled degradation process. Trigger units are stimuli reactive small molecule endcaps that, when cleaved, allow for the end-to-end depolymerization of the SIP. By studying small molecule trigger units, we present a multi-stimuli trigger that utilizes orthogonal chemistry to impart control over the triggering event and thus the degradation process. By controlling this cleavage reaction, we achieve temporal control over the depolymerization and subsequent release of cargo from the SIP.

Development of a logic controlled trigger unit for self-immolative polymers

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.