The interaction of vanadate and other polyoxometalates with amino acids and proteins has been examined for several decades and the coordination geometries are described in detail by crystallographic studies.  Using data mining methods we have examined the known crystal structures of oxovanadates in small molecules and in proteins and compared to the corresponding structures of other oxometalate structures in protein environments. We have previously applied insights from the fundamental coordination chemistry of simple vanadium coordination complexes to understand the interactions with proteins in general including phosphatases and haloperoxidases.  Here we discuss the latest insights in investigating the geometries of polyoxometalates in general, highlighting decavanadate and the Wells-Dawson cluster, and their interactions with protein complexes in enzymes and the ribosome.  We will also discuss the implications for biological activities.<br/>

Interactions of polyoxometalates with proteins

2019 Spring National Meeting

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