Two derivatives of Lewis X tetra/pentasacchride antigen are assembled in one-pot by preactivation of thioglycosides. Following deprotection of preinstalled ester groups on Lewis X antigens, another fucose unit is introduced to construct the Lewis Y derivatives. The syntheses of four antigens are achieved in a highly efficient manner by preactivation of thioglycoside donors and employment of shared key intermediates. Subsequently, immunologic studies of these derivatives that sharing same core structures are performed to provide insights into the SAR of antigen recognition in immune response.

Efficient synthesis and structure-activity relationship studies of Lewis X / Y class antigens

2019 Spring National Meeting

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