Alzheimer’s disease is a type of dementia in which patients are found to have beta-amyloid aggregations that form into plaques and further degrade the patient’s brain function. Curcumin, a compound commonly found in turmeric, has been found to decrease beta-amyloid plaque formation. One of the drawbacks of Curcumin is its poor bioavailability. Literature results suggested that conversion of Curcumin to a metal complex not only addressed the poor bioavailability but also showed increasing anti-cancer and anti-oxidant activities. This experiment primarily focused on enhancing the effect of Curcumin on beta-amyloid aggregation by converting it into Curcumin-Metal complex. The metals chosen were Aluminum and some d-block elements such as Zinc, Copper, Cobalt, and Gallium that have been previously shown to augment the properties observed in Curcumin. These metal complexes showed promising results in delaying the kinematics of the beta-amyloid aggregation.

Curcumin-metal complexes as inhibitors of beta-amyloid aggregation

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.