Biotemplated nanomaterials offer great promise in multimodal imaging, biosensing, and molecular delivery. There remains an unmet need for traceable and biocompatible nanomaterials that can be synthesized in a precisely controllable manner. This presentation will focus on self-assembled DNA quantum dot nanostructures with controlled sizes that incorporate multiple functionalities for biological applications. We successfully synthesize Quantum Dot-DNA Hydrogels by incorporating DNA-templated quantum dots into a hydrogel network in a single step and introduce multifunctionality for a variety of applications, including enzyme-responsive drug delivery and cell-specific targeting. Subsequently, we demonstrate the use of programmable “core-satellite” metal/semiconductor nanostructures for mRNA sensing and drug delivery in drug-resistant cells, which could effectively enhance therapeutic efficacy. The works pave the way for the development of new tunable biotemplated nanomaterials with multiple synergistic functionalities for biomedical applications.

Programmable DNA-semiconductor nanostructures for molecular delivery

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.