In this poster we discuss the synthesis and characterization of discrete zinc metal-organic materials (MOMs) also known as nanoballs.  The nanoballs were synthesized by the reaction of zinc nitrate and 5-hydroxyisophthalic acid derivatives to create structures with variable hydrophobicity, size and shape.  We also investigated the effects of templates, solvents, and reaction conditions, i.e. layering method and microwave reactor, on the structures of the nanoballs.  The use of these nanoballs as drug delivery agents was investigated by monitoring the uptake and release of ibuprofen under physiological conditions.  Molecular mechanics and density functional theory (DFT) were used to elucidate the optimized geometry of the Zinc MOMs and understand the binding interaction of pharmaceuticals with the nanoball carriers.

Preparation of zinc metal-organic materials towards drug delivery vessels

2019 Spring National Meeting

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