There is great interest in the scientific community and pharmaceutical industry in developing mechanisms to control biological processes at the cellular level. A particularly intriguing concept is to regulate material transport across biologically important membranes by external magnetic stimuli. In this work, we demonstrate the ability to prepare liposomes loaded with model drug and magnetic particles. The magneto liposomes when triggered with inhomogeneous pulsed magnetic fields release drug molecules. We have discovered that the mechanism of drug release is the result of the ultrasound generation from small magnetic nanoparticles. The ultrasound is generated from the movement of particles in inhomogeneous magnetic fields as opposed to the much weaker magnetostriction effect due to homogeneous magnetic fields. While magnetic heating from low frequency is also used for drug release from liposomes, this work has achieved comparable efficiency on the sub millisecond time scale using intense pulsed magnetic fields (few Teslas) as opposed to extended use of low frequency magnetic fields. While inhomogeneous magnetic pulses provide an effective tool, we also have developed a homogeneous rotating magnetic field generator that will be used in the next phase to generate mechanical motion from directional change of anisotropic magnetic structures. Preliminary data on the characterization the rotating magnetic field generator is also shown.<br/>

Shaping magnetic fields for effective drug transport across liposome membranes

2019 Spring National Meeting

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