Inspired by the success of automated oligosaccharide synthesis through chemical glycosylation, a machine-driven automated system is reported here for oligosaccharides and glycopeptides synthesis through solid-phase peptide synthesis (SPPS) in organic solution and enzymatic glycosylation in aqueous solution. Thus, chemoenzymatic synthesis of oligosaccharides and glycopeptides can be obtained in an automated manner using a commercially available peptide synthesizer.

Machine-driven chemoenzymatic synthesis of oligosaccharides and glycopeptides by a peptide synthesizer

2019 Spring National Meeting

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