Likely due to the lesser degrees of control exhibited, there has been significantly less work done on the polymerization of 2-oxazines to produce linear poly(trimenthylenimine) (LPTMI) compared to the polymerization of 2-oxazolines to produce linear polyethylenimine (LPEI). LPTMI, which has an additional methylene spacer compared to LPEI, can also be utilized in non-viral gene-transfection. Recently, we have produced LPTMI through a controlled, living anionic ring-opening polymerization of sulfonylazetidines.<sup>1,2</sup> After post-polymerization removal of the sulfonyl groups, this finding yields polymers with high degrees of control over both the target molecular weight and dispersity, which are essential in applications of non-viral gene-transfection.

Synthesis of linear poly(trimethylenimine) by living anionic ring-opening polymerization

2019 Spring National Meeting

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