An increasingly strong body of evidence suggests that the human microbiome play fundamental roles in the host’s health and disease. The past decade has seen remarkable progress in this research area, driven largely by the rapid advance of culture-independent sequencing technologies. However, the basic question of how the diverse microorganisms interact with one another and with their host functionally remains largely unanswered, because of the immense ecological complexity and the challenge in isolating microbes using conventional cultivation methods. To address this issue, we have been developing a microfluidic co-cultivation and analysis technological platform for elucidating interspecies interactions that play a key role in shaping the structure and function of various microbiomes. In this talk, we will focus on the newest modules in our expanding microfludic toolbox, including individual microdroplet isolation and metagenome analysis. In addition, we will show results from applying the technologies to the human gut and vaginal microbiomes.<br/><br/>

Elucidating interspecies interactions as a key ecoloical driver of microbiome structure and function:  microdroplet co-cutivation technology and its applications

2019 Spring National Meeting

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