Caffeine interactions with cations and osmolytes are investigated by a combination of thermodynamic and spectroscopic approaches. Effects of a series of chloride salts and osmolytes on the thermodynamics of caffeine partitioning between aqueous and cyclohexane are studied by using UV-vis spectroscopy. Standard Gibbs free energy for caffeine transfer is measured as a function of cation and osmolyte concentration and solution temperature. Standard enthalpy and entropy for caffeine partitioning in the presence of chloride salts and osmolytes are obtained. On the other hand, 1H and 13C NMR and ATR-FTIR spectroscopy are employed to determine how cations and osmolytes interact with caffeine. The spectroscopic experiments complement the thermodynamic measurements to illustrate the specific interactions of cations and osmolytes with caffeine molecule in solution.

Studies of caffeine interactions with cations and osmolytes

2019 Spring National Meeting

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