Herein, we describe a method for the synthesis of new poly(2-alkyl-2-oxazoline)s (PAOx) based on poly(2-ethyl-2-oxazoline) (PEtOx). A well-defined linear polyethyleneimine was first prepared from PEtOx by controlled acidic hydrolysis of its side-chains followed by re-acylation with different carboxylic acids. The described synthetic protocol is universal and can be extremely versatile, especially for PAOx that are difficult to prepare by conventional cationic ring opening polymerization due to the monomer interference or degradation. To demonstrate the versatility of this protocol, we synthesized a series of new “superhydrophilic” PAOx containing side-chain ether groups with potential in the biomaterials science, a series of high molar mass poly(2-methyl-2-oxazoline)s, as well as different thermosensitive poly(2-dialkylamino-2-oxazolines).

Straightforward route to new poly(2-oxazoline)s <i>via</i> acylation of well-defined polyethyleneimine

2019 Spring National Meeting

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Straightforward route to new poly(2-oxazoline)s via acylation of well-defined polyethyleneimine