<b>Abstract. </b>Reactive oxygen species (ROS) are highly active chemical reagents that oxidize lipids, proteins, and nucleic acid in cells. Under normal circumstances, ROS play an important role as secondary messengers involved in cellular signaling. However, elevation of ROS levels due to intracellular overproduction or extracellular exposure can cause oxidative stress in cells, which is responsible for irreversible damage and disease. To address this, many strategies have been implemented to neutralize excessive ROS including the administration of conventional antioxidants and ROS scavengers.  These approaches, however, in general, fail to achieve the desired efficiency because of the limited cellular uptake of the low-molecular-weight ROS scavengers such as nitroxide derivatives. Recently, nanoparticle (NP)-mediated delivery of ROS scavengers has received attention as the small NP carriers can be loaded and delivered into cellular/subcellular locations. In this study, we have formulated a nitroxide derivative, 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO), that is conjugated to the surface of liquid crystal NPs (LCNP-TEMPO) that can preferentially bind to the plasma membrane and protect the cells from excessive exposure to ROS sources (e.g., hydrogen peroxide). The ability of LCNP-TEMPO to protect cells from intracellular or extracellular exposure of ROS will be discussed.  <br/>

Nitroxide-liquid crystal nanoparticle conjugates for the protection of cells against reactive oxygen species

2019 Spring National Meeting

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