An injectable supramolecular hydrogel with stimuli-responsive and sustained drug delivery ability were prepared from gelatin and β-cyclodextrin-grafted chitosan nanoparticles through host-guest interactions between the gelatinous aromatic residues and β-cyclodextrin (β-CD). Nanoparticles with a diameter of ca. 200 nm were prepared from b-cyclodextrin-grafted chitosan (CS-g-CD) through ionic crosslinking induced self-assembly by electrostatic interactions between positively charged amino group in CS-g-CD and negatively charged phosphate in sodium tripolyphosphate (TPP). The gelation kinetics, hydrogel strength and shear viscosity could be modulated by the CS-g-CD nanoparticle concentration in the hydrogel. Doxorubicin (DOX)-encapsulated hydrogel <i>via</i> the nanoparticles exhibited pH- and temperature-triggered DOX release in simulated tumoral microenvironment. <i>In vitro</i> experiments indicated that the DOX-loaded supramolecular hydrogel could result in the sustained tumor cell inhibition meanwhile showed good biocompatibility. As an injectable drug delivery system, this supramolecular hydrogel appears to have bright prospects as a promising candidate for tumor treatment.

Injectable supramolecular hydrogel formed from gelatin and cyclodextrin-grafted chitosan nanoparticles for pH-responsive drug release

2019 Spring National Meeting

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