Colloidal Gold nanostructures are promising materials for biomedical applications because of their good biocompatibility and their unique optical properties. Here we used different kinds of Gold nanostructures such as Gold nanoparticles (AuNPs), Gold nanorods (AuNRs), and small Gold nanoclusters (AuNCs) to investigate their interaction with cells. Besides size variation we functionalized their surface with aptamers for a specific interaction with BaF3 cells for different biomedical applications. By using different analytical and optical methods (ICP-MS, confocal spectroscopy, FLIM) we could show that after a short incubation time the particles are already binding to the cells and are internalized by receptor-mediated endocytosis.

Gold nanoparticles for specific binding and internalization in cells

2019 Spring National Meeting

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